Levulan® Kerastick®

(aminolevulinic acid HCl) for Topical Solution, 20%

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LEVULAN KERASTICK for Topical Solution, 20% Preparation

LEVULAN KERASTICK can be prepared either manually or by using the optional Kerastick Krusher™.  These methods are illustrated below and are followed by additional preparation tips.

Manual Preparation:

 

 

 1. Hold the LEVULAN KERASTICK so that the applicator cap is pointing up.

 

  

 2. Crush the bottom ampule containing the solution vehicle by applying finger pressure to Position A on the cardboard sleeve.

 

 

 3. Crush the top ampule containing the ALA HCl powder by applying finger pressure to Position B on the cardboard sleeve. To ensure both ampules are crushed continue crushing the applicator downward, applying finger pressure to Position A.

 

 4. Holding the LEVULAN KERASTICK between the thumb and forefinger, point the applicator cap away from the face, shake the LEVULAN KERASTICK gently for at least 30 seconds to completely dissolve the drug powder in the solution vehicle. Do not press on the end cap while shaking.

 

Optional Kerastick Krusher Preparation:

 

      Closed End                           Open End

      ↓                        ↓

1.  Open the Kerastick Krusher and properly position one LEVULAN KERASTICK into the Krusher making sure to orient the LEVULAN KERASTICK label “A” with the Krusher “A”. Firmly seat LEVULAN KERASTICK against the closed end of the Krusher (cap should be at open end).

 

 

2.  Once positioned properly, close and firmly press the top and bottom handles together until the top and bottom handles touch one another along their length. A distinct crushing sound is made during this process. Ensure Krusher handles meet.

 

 

 3.   Remove the LEVULAN KERASTICK from the Krusher.

 

 

 4.  Holding the LEVULAN KERASTICK between the thumb and forefinger, point the applicator cap away from the face, shake the LEVULAN KERASTICK gently for at least 30 seconds to completely dissolve the drug powder in the solution vehicle. Do not press on the end cap while shaking.

 

 

TIPS: 

  • Ensure the applicator cap remains pointing up during crushing.
  • Do not press on the cap while shaking.
  • Activate the flow of solution through the tip by dabbing the tip on a gauze pad until uniformly wet. 
  • After activation, the user may want to tap the closed end of the applicator onto a flat surface to settle the glass residue away from the tip prior to use.

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